Endocrine diseases

Pituitary dwarfism

pituitary dwarfism

pituitary dwarfism pituitary dwarfism (dwarfism) - a disease characterized by a delay of physical development and growth associated with insufficient secretion of growth hormone (GH) by the anterior pituitary.According to statistics, the disease is very rare - from 1 to 4 cases per 10,000 population (boys respect girls get sick twice as often). Height considered undersized if the men below 130 cm and women below 120 cm


- Head Injury (generic and so forth.)

- Tumors of the pituitary gland and surrounding nerve tissue

- Birth defects (violationthe formation of the pituitary gland in utero)

- Moved chemotherapy and radiotherapy

- Postponed disease ( sarcoidosis, syphilis, tuberculosis )

In about 60% of cases, the cause of pituitary dwarfism can not be established


In most cases, growth retardation is revealed in the first months of life, but the more obvious signs begin to appear at the age of two - three years (very rare in puberty).The growth rate decre

ased markedly and no more than three - four centimeters per year (at a rate of seven - eight centimeters), the proportions of the body remain normal.There backlog age differentiation and ossification of the skeleton, there are developmental disorders and dentition.The skin becomes pale, wrinkled, dry;subcutaneous fat developed very weakly.Sometimes there may be excessive deposition of fat in the thighs, abdomen and chest.The muscular system in patients with pituitary dwarfism significantly weaker than that of ordinary people.There is a reduction in the size of internal organs, often revealed hypotension may occur bradycardia hypotheses and possible secondary effects and secondary hypocorticoidism hypothyroidism .Mental development in this disease is usually in the normal range (observed in patients with a good memory).

were significantly reduced production of sex hormones (hypogonadism), which can be traced due to explicit sexual underdevelopment.Men: penis and gonads significantly reduced, the scrotum is underdeveloped, no secondary sexual characteristics.In women: missed periods, breast underdeveloped, mild secondary sexual characteristics


treatment of pituitary dwarfism is carried out using replacement therapy and is systematically administered to purified preparations of growth hormone.To facilitate administration and dosage of growth hormone injection syringe designed - handles (like insulin).Thanks to the treatment, the growth rate in most cases increases to 8 - 12 cm. Per year.The treatment regimen during puberty necessarily involve hormones.Approximately every fifth case, a deficiency of growth hormone deficiency is accompanied by pituitary hormones.In these cases, the regimen must include thyroid hormones.Patients need to stick to a diet with an increased content of vitamins and protein.dwarfism

prognosis for life in the form of genetic pituitary dwarfism is quite favorable.In case the presence of organic brain damage disease prognosis is basic.

More articles on the topic:

1. Hypogonadism 2. Hyperthyroidism

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