May
14
23:01
Vascular disease

Buerger's disease

Buerger

Buerger photo Buerger's disease (thromboangiitis obliterans) - an inflammatory systemic disease of supplying the medium and small vessels, with elements of autoimmune nature.The disease most often affects younger men, the most widespread disease received in South Asia, India, Japan and Israel.It should be noted that the inflammatory process violates not only the proper functioning of blood vessels, but also due to impaired circulation and delivery of nutrients affected surrounding tissue

Causes of Buerger's disease

at the origin of Buerger's disease is thrombosis of venous and arterial vessels of the lower or/ and upper extremities and abnormal acute inflammation.The mechanisms of these processes is not yet understood, but it is believed that some role in the origin and development of the disease play immunological reactions.In addition, it has suggested that the main reason for provoking Buerger's disease can be regarded as tobacco.It has long been proven that nicotine is a thrombogenic mate

rial and therefore we can confidently assert that smoking increases the chance of developing thrombosis.

also identified the following potential factors of development of the disease:

• Neuroendocrine factor.Due to the high level of adrenaline in the blood (as a result of increased adrenal function), in the microcirculation system develops spasm

• infectious factors.This disease is similar to chlamydia, streptococcus, and viral infection salmoneleznoy

• neurogenic factor.Due to take place in the nerve trunks of organic changes, develops and thrombus occlusion of peripheral artery disease, spastic dystrophy

• damaging factors.Intoxication by arsenic, frostbite, injury and allergic reactions

• Genetic factors.Usually there is endemic

• Autoimmune factor.Generates autoantibodies to elastin, collagen, laminin, endothelial cells to form circulating immune complexes (CIC) and the development of antiphospholipid syndrome

Buerger's disease - symptoms

Buerger's disease most often takes the start with the defeat of the small arteries of the hands and feet.The main factor for the development of a pronounced inflammatory process causes the later stages of the disease and arterial occlusion venous and squeezing overgrown connective tissue all neurovascular bundle.The disease progresses very quickly, there are frequent exacerbations provoked by smoking or cold.Distinctive symptoms suggestive of the disease is not present.Diagnosis is based on indirect signs that could indicate the disease.

symptoms of Buerger's disease always develops gradually.At the initial stage of the disease is usually observed frequent tingling and coldness in the fingers, tired limbs.After that there is pain when walking, not diminished, even in moments of relaxation, there is swelling and cyanotic color of the limb may be present intermittent cramping fingers.When running form of the disease due to impaired blood flow to the surface of the skin can develop sores, which, if untreated, lead to gangrene and amputation of the affected limb inevitable Photo Buerger

Diagnostics Buerger's disease

Diagnosis is difficult, therefore, often the diagnosis is exclusive, that is,Buerger's disease is confirmed in the case of failure to prove the existence of other causes for the development of the above symptoms.The diagnosis is established when the patient following criteria:

• Smoking, patients younger than 45 years

• The limb tissues present signs of circulatory failure: intermittent claudication, ulcers, pain

• During the US determined a violation of the vascular circulation

• The laboratory tests rule out diabetes and autoimmune diseases

• Conduct echocardiography excluded the sources of embolism

• Same as in the patient, in a healthy limb reveal similar changes

Buerger's disease - treatment

Today effective methodsallowing completely cure Buerger's disease has not been developed.First of all, the treatment of the disease starts with a clear smoking cessation.For the development of vascular kollateraraley certainly recommend dosed walking.Vasospasm eliminate using nicotinic acid drugs, peripheral anticholinergics (padutin, andekalin) ganglioblokatorov and antispasmodics.To normalize the functioning of the central nervous system used anxiolytics and sedatives.Patients with secondary infection shows antibiotics.For the normalization of anticoagulant and blood clotting appointed anticoagulants (fraxiparine, Clexane, Heparin).To increase the flow of blood in the capillaries prescribe clopidogrel and aspirin.

Surgical treatment of Buerger's disease is to carry out such radical surgery as the bypass (bypassing the narrowed arterial section creates a shunt) endarterioektomiya (for artery blockage is removed the vascular endothelium), prosthetics (installation explants) and stenting (in the vessel is the frame-wall).When necrosis of the affected finger amputation of the upper limb is held.When gangrene of toes or entire feet held economical (low) amputation

forecast Buerger's disease .Unfortunately, more than 35% of patients with Buerger's disease is not able to avoid amputation.More often, the affected parts of the limbs amputated people who do not heed the warnings and continued to smoke.Related diabetes also adversely affects the future quality of life

More articles on the topic:

1. Behcet's disease

2. idiopathic thrombocytopenic purpura

3. Atherosclerosis

Services Selectiondoctor is relevant only for the citizens of the Russian Federation