Bowen's disease (intraepidermal cancer) - single or multiple tumors of the skin, localized in their surface layer - the epidermis.Due to the lack of germination epidermal cancer in the surrounding tissue, the disease refers to precancerous diseases and in the absence of treatment is usually transformed into invasive cancer of the skin with further growth and metastasis have a malignant tumor.
Bowen's disease most often occurs in older people of both sexes, although occasionally can be seen at almost any age.Main localization intraepidermal skin cancer:
→ 10% - mucosal
→ 10% - sexual organs
→ 15% - palm
→ 45% - head
genital these tumors most often localized in uncircumcised menin the age range from forty-five to seventy years on the inner surface of the foreskin, female genital this type of cancer is extremely rare
Bowen's disease - causes
For reasons of Bowen's disease include some chronic dermatoses (dystrophic epidermolysis bullosa, discoid lupuserythematosu
Bowen's disease - symptoms
intraepidermal cancer can occur anywhere on the mucous membranes and skin.Initially Bowen's disease of the skin appears reddish-brown circular spots with jagged borders, which over time transformed into a few rise above the surface of the skin plaques with slightly raised edges around the perimeter of the hearth.Gradually, the plaque becomes red with copper-coated flakes flaky surface.The scales are usually white or yellow, they are easily removed from the plaque by exposing a non-bleeding visible weeping surface.In the transition from the precancerous disease Bowen cancerous condition, ulcerated plaque.
size of the lesion can range from two millimeters to five centimeters.As the tumor on the surface of the plaques appear warty growths, portions and elements hyperkeratosis atrophy.The lesion was characterized by elevated edges and uneven growth.
Bowen's disease usually occurs one lesion, but sometimes noted the appearance of several nearby plaques that with further growth are beginning to merge.This localization neoplasm on the mucosal surface, the plaques are usually papillomatoznyh velvety surface.In the case of the focus position in the nail area around there is peeling, and progression, the nail plate is melted and ulcerate.In rare cases, a so-called pigment form intraepidermal cancer, which is characterized by dark brown color plaques
Bowen's disease - diagnosis
diagnosis of malignancy based on data from histological studies and visual inspection of the lesion.Histology intraepidermal cancer is fully consistent with squamous skin cancer, but the plaque is not to be striking the dermis and is exclusively within the epidermis.Differential diagnosis of Bowen's disease is carried out with the following diseases: Bowenoid papulosis, lupus, flat surface bazilioma, senile warts, eczema, psoriasis, solar keratosis
Bowen's disease - treatment
For small-sized outbreaks (two centimeters), treatmentBowen's disease is the use of application of 5% and 50% ftoruratsilovoy prospidinovoy ointments.If no positive effect, treatment is performed by surgical removal of the neoplasm.When the diameter of the lesion more than two centimeters shows the types of radical treatment such as removal of the focus by using a carbon dioxide laser, electrosurgical, and surgical removal, cryosurgery.In the case of localization of cancer in the mucosa, shows the use of 5% ointment ftoruratsilovoy + aromatic retinoids inside (tigazon - a daily dose of 1 mg / kg, rate of one to two months).
Because Bowen's disease already in its early stages of development can be transformed into a squamous cell carcinoma of the skin and has a rapidly progressive course, the prognosis is not very favorable.That is why a favorable outcome is necessary to conduct timely adequate treatment before malignant transformation.A wrong method of treatment of this tumor often leads to relapse.