sarcoma of the uterus - is a rare highly malignant tumor of the cervix or uterine body, on the specifics of the treatment course, and metastasis is very different from cancer of the uterine body.Sarcoma of the uterus can affect in addition to the uterus and its neck of the ovaries, fallopian tubes and vagina.This cancer process occurs at any age, but more common in women after forty years.Uterine sarcoma is characterized by rapid growth and hematogenous metastasis in the vaginal wall, bone, liver and lungs.For this disease is characterized by invasive growth with the rapid penetration into nearby tissues and organs.Localization often (10! Times) infestation uterine body itself than its neck.
types of uterine sarcoma: carcinosarcoma and leiomyosarcoma (80% of all sarcomas of the localization), endometrial stromal sarcoma (15%), angiosarcoma and clean sarcoma (no more than 5%)
sarcoma of the uterus - the reasons
unequivocal answerthe question of the exact cause of uterine
Usually uterine sarcoma precede those pathological conditions like fibroids, birth injuries, violations of embryogenesis damage after surgical abortion, endometrial polyps, endometriosis and so forth.
Considerable importance is attached to occupational hazards, exposure of a small basin in the diagnosis of cervical cancer, unfavorable environmentalthe situation in the place of residence, chronic intoxication (drugs, alcohol, nicotine, etc.).It is also not excluded that the development of this cancer contributes significantly hyperestrogenia, anovulation and arising during menopause endocrine disorders
sarcoma of the uterus - the symptoms
If you have progressive sarcoma of the uterus is not every woman in a hurry to see a doctor because the typical cancer symptomsmost cases completely absent.Sometimes a woman thinks that the observed symptoms associated with any other state, and all held their own.Sarcoma of the uterus due to insufficient symptom refers to the so-called "silent tumors."Even already in the last stages of the flow, it can not show anything.Anxiety often beaten already when there are bleeding, severe pain in the pelvis, cycle disorders, and suppuration.Unfortunately, in such cases, the chance for a normal outcome of future treatment is minimal as the cancer process has already passed stage III, and it minimizes the positive result.
main symptoms of uterine sarcoma: the rapid growth of the tumor, roughness, palpation pain and irregular texture, acyclic uterine bleeding, anemia, infection increases with the accession tempera.body, joins symptoms of compression of the rectum and bladder, general malaise, fatigue, late pain, limited mobility tumor
Stages of sarcoma of the uterus
• Stage I. In this stage uterine sarcoma limited to mucosal and / or muscle layer.At stage Ia affected myometrium and endometrium.At stage Ic affected endometrium and myometrium and
• Stage II.Sarcoma is limited to the neck and body of the uterus, beyond them the tumor has not come out.At stage IIa observed proximal or distal not passing on the pelvic wall infiltration parameters.When tumor stage IIb passes the cervix
• Phase III.Sarcoma is outside the uterus, but remains within the boundaries of the pelvis.If there is a two-stage IIIa-sided passing to the pelvic wall infiltration parameters.When the germination stage IIIB observed large veins, metastasis in the epididymis, vagina, and regional lymph nodes.For stage IIIc characterized by the formation of conglomerates with nearby structures and germination serous pokrova uterus
• Stage IV.Sarcoma of the uterus invades adjacent organs and beyond the pelvis.At stage IVa tumor invades the rectum and bladder.At stage IV in distant metastasis observed
uterine sarcoma - diagnosis
Diagnosis of uterine sarcoma is difficult enough.Suspect the presence of a tumor can be in the presence of the following signs: acyclic bleeding, rapid growth of fibroids or uterine tumors, increased erythrocyte sedimentation rate, anemia without blood loss, a significant deterioration in the general condition, after supravaginal hysterectomy in the cult of developing tumor recurrence after removal of submucous nodes and polyps.
On examination of the vagina special attention to the pay cyanotic color of the cervix, its hypertrophy and swelling and sometimes emerging sarcomatous node.With bimanual rectovaginal pelvic exam or a set place localization of uterine sarcoma, texture, size and displaceability nodes, the presence of infiltrates in the parameters and the state of appendages.Ultrasound - diagnostics detect the presence of abnormal blood flow, necrotic nodes, node transformation of the uterus and its possible heterogeneous echogenicity.Needle aspiration cytology with a further biopsy helps to determine the possible presence of atypical polymorphic cells.Also, all patients with sarcoma of the localization of the next survey shows: chest X-ray, liver ultrasound, barium enema, sigmoidoscopy, renography, cystochromoscopy, excretory urography.
During the diagnosis of uterine sarcoma should be differentiated from diseases such as primary tumors adjacent localization of endometrial polyps, ovarian tumors, uterine fibroids.
Visual inspection of the cervix, sarcoma is a type of cancer, so the diagnosis is to be confirmed only after histological examination.The duration of the disease, since the detection of the first symptoms of a sarcoma is about two years.Most often, patients die from pneumonia sarcomatous (metastases struck the lungs), or from the abundant intra-uterine bleeding, peritonitis, pyelonephritis, and uremia;infrequently from liver failure
uterine sarcoma - treated
Usually surgical treatment of uterine sarcoma, sometimes combined (added to radiation and chemotherapy).The most effective intervention is considered to be a radical total removal of the uterus, appendages, regional lymph nodes affected blood vessels, and at advanced stages may be disposed adjacent organs and metastases visible.According to the testimony
surgical treatment may be supplemented by radiotherapy.Chemotherapy because of its lack of efficacy in the treatment of this disease is used for recurrent uterine sarcoma and inoperable tumors.
forecast uterine sarcoma quite disappointing.Five-year survival rate of stage I is not more than 45% in stage II - 40% with stage III - less than 40% in stage IV and less than 10%.