large-Lymphoma - a malignant pathology of the lymphatic system, at which uncontrolled growth and division of tumor cells without the withering away of the old, as is characteristic of a healthy body.Lymphoma can affect large- any part of the body, while developing in the lymph nodes, and in conjunction with the internal organs.
a result of displacement of normal, healthy bone marrow cells, this anomaly violates the formation of red blood cells that are involved in the delivery of oxygen, protecting the body from infections and platelets.A reduced number of platelets causes many bleeding.
large-Lymphoma has several types.These include mediastinal diffuse, anaplastic, B large- lymphoma.This disease has no age limit, affects many lymph nodes located in the gastrointestinal tract, peritoneum, testicles, neck, and extends to the salivary glands and thyroid, bone and brain.With the progression, it involves in the pathological process of the lungs, kidneys and liver.
Lymphoma causes large-
This malignant disease accounts for nearly 4% of all cancer tumors.Recently, this pathological process has a strong tendency to increase.And men are affected more often than women and with increasing age, these figures are much increased.However, large-cell lymphoma affects the children's age.
Etiologies occurrence of malignant disease allegedly include Epstein-Barr virus and Helicobakter pylori.There is speculation that the development of large-lymphoma important role played by chronic myelosuppression, which occurs after the transplantation of somatic organs.Also, back in 1972 we made the first description of certain chromosomal abnormalities that caused the formation of large-lymphoma.Thereafter, it was revealed several chromosomal changes that correlate with this disease.
Many medical scientists to predisposing factors in the formation of lymphomas include large-acquired or congenital immunodeficiency abnormalities, chronic antigenic stimulation and infection caused by different viruses.
Diffuse large cell lymphoma
This disease is a component of a class of aggressive large cell lymphoma.B cells or lymphocytes play a role searchers foreign cells and then detecting when transmitting signals to the immune system.The main role in this chain belongs to the lymph nodes that have a certain structure and divided by the corresponding area.And all of them while performing their functions.During the development of diffuse large lymphoma occur violations of the structure.As well as malignant cells localized diffusely i.e.located in all tissues and organs, and therefore the disease got its name.
Diffuse large cell lymphoma can affect any part of the body, but mostly it spreads to the lymph nodes in the neck, groin and underarms.On palpation can easily identify these enlarged lymph nodes.In addition, they are free to be seen in the surveys on the ultrasound or radiography.
for clinical diffuse large lymphoma is characterized by rapid weight loss, heavy sweating, especially at night, and a high rise in temperature.This disease can develop both individually and as a result the impact of other lymphomas.
shared by several types of the disease.Regular diffuse large lymphoma belongs to the most common and frequent form of the disease.In second place among this disease is lymphoma with an excess amount of histiocytes and T cells.There is also a primary lesion of the brain during diffuse large cell lymphoma and primary cutaneous abnormalities and more isolated in the large cell lymphoma, diagnosed with Epstein-Barr virus and chronic inflammation.
Usually, diffuse large cell lymphoma tend to rapid progression and spread, but, nevertheless, it is a good idea treatable.
for correct diagnosis on the biopsy material taken from an enlarged lymph node or tumor itself for immunohistochemical studies and morphological character.In addition, if necessary, administered tomography pelvic, abdominal and chest.For staging system is used «Ann-Arbor», pointing to the bodies ravaged by the disease.
The main methods of treatment of pathological diseases include chemotherapy and radiation exposure.For the first option treatment using modern methods of drug administration.These include the administration of drugs through the spinal canal, intravenous central catheter, subcutaneous venous ports or catheter type PICC.
Since large-cell lymphoma is a rapidly progressive tumor, for its treatment of high doses of chemotherapy drugs.Typically, such drugs are administered intravenously in combination with monoclonal antibody therapy.Such large-treatment of lymphoma patients can receive outpatient and, if necessary, hospitalization may be indicated, which can be extended for a while.
In those cases where the cancerous process involves the central nervous system, all chemotherapy drugs are introduced lumbar puncture.These medications include: Prednisone, Oncovin, doxorubicin and cyclophosphamide.
Lymphoma large-sometimes been perceived high polychemotherapy.Therefore, assuming the occurrence of relapse after the end of treatment, the doctors propose to hold high-dose chemotherapy.
For the treatment of this disease after chemotherapy and radiotherapy may designate.Especially, it concerns the localization of large-lymphoma in only one area of lymph nodes.
In children the disease occurs in a very severe form of high aggressiveness.The basis of treatment is the same chemotherapy in combination with radiation.
lymphoma large-radiotherapy is used topically.It involves the irradiation of certain affected areas.Basically, this is one or two groups of enlarged lymph nodes.It is much more efficient use of radiation therapy for the first and second stages of the disease when the affected lymph nodes are located only on one side of the body.Very often this treatment is carried out in parallel with lekartvennym course.
beam radiation consists of small daily sessions for 10-15 minutes, that must take place in the radiology department.After the courses make a break.
mainly to chemotherapy in the treatment of lymphoma, four large-used formulation comprising a combination of CHOP.At the same time the drug Rituximab is appointed to support the immune system.
main aim set for chemotherapy - is to achieve absolute remission status at least in the initial stages of treatment, since it increases the survival rate of patients.
Current therapies allowed to reach this curable disease.
Five-year survival in the large-cell lymphoma is already 85% for the first risk factor, but for the fourth and fifth - only 26%.In these terms the main aspect considered appropriate treatment to correct an initial diagnosis of the disease.