dyskeratosis - a disease which is a physiological disorder of keratinization, which is expressed in certain pathological keratinization of epidermal cells.Dyskeratosis clinically distinguish between two types - malignant and benign.Malignant characterized keratinization immature and atypical cells, which tend to Bowen disease and may also be squamous skin cancer, actinic keratosis and certain precancerous skin diseases.
Benign dyskeratosis occurs with Darier's disease, with clams and marked the formation of grains and round cells.The term dyskeratosis apply for some diseases associated with violation of keratinization.This refers to the follicular dyskeratosis.
This type is a hereditary disease, expressed in violation of the processes of keratinization and follicular hyperkeratotic papules occur in seborrheic areas.The disease is inherited in an autosomal dominant person, and the gene is concentrated in the 12q23-q24.1.Both men and women are equally
follicular dyskeratosis reasons .The causes of the disease is considered failure of vitamin A change of metabolism of unsaturated fatty acids, the variability of the ratio of inhibitors and activators of proteases, their localization or activity.
follicular dyskeratosis signs .The first signs are the appearance of a plurality of giperkeraticheskih papules, whose first color is not particularly stands out from the color of natural skin, but over time becomes grayish-brown hues.The rash is covered with crusts, first isolated and basically follicular, then merge into verrucous lesions and vegetating lesions, localized in the folds and accompanied by weeping.Advantageously, the elements are located on the skin of the person for auricles, scalp, between the blades in the region of the sternum, in the folds, but can be located throughout skin.
dyskeratosis able to hit the vagina, mouth, rectum, larynx, corneal esophagus.
Sometimes there are linear, vesicular-bullous, localized, zosteriformnye form of the disease, as well as warty diskeratoma.Often found nail dystrophy, cystic bone changes, keratoses as points on the soles and palms, cystic bone changes.There is a decrease of intelligence, epilepsy, mental retardation occurrence, psixicheckie disorders, hypogonadism, impaired growth, changes in the immune system that promotes adherence of viral and bacterial infections varioliform rashes and fungal lesions.
One of the manifestations may be numerous, small, polygonal papules natural color or color with a reddish tinge on the back of the feet and palms as well as verrutsiformny akrokeratoz Hopf.
Elements rash can sometimes acquire warty surface or merge into verrucous pockets.Rash capable positioned at other locations of the skin, and thus form a diffuse, a slight thickening of the horny layer, the papillary lines of discontinuity, the point keratosis.
diagnosis of follicular dyskeratosis .Diagnosis is made after a visual inspection of lesions in seborrheic areas, as well as data and histological studies of the differential separation of the following diseases: seborrhea, pemphigus, pyoderma, acne.
follicular dyskeratosis treatment .Assign vitamin A, Tigazon, salicylic ointment, or sulfur-salicylic ointment urea, topically, aniline dyes, antibiotics.Verrucose akrokeratoz treated diatermokoagylyatsiey.It is recommended to gently apply the ultraviolet and preparations containing lithium.
second title of the disease is leukoplakia, which tend to actinic squamous epithelium covering the cervix and vagina.Dyskeratosis cervical exists in two forms: simple and scaly.
Simple dyskeratosis appears on the cervix, while behaving asymptomatic and difficult to see.Scaled dyskeratosis hitting the cervix and protruding above the surface, appears as whitish plaques on the pink background of the cervix.
dyskeratosis causes cervical .There are endogenous and exogenous factors of the disease.Endogenous include hormonal changes in hemostasis and reduced immunity.Exogenous causes include infections, chemical, viral, traumatic effect on the body.Not the least role in the occurrence of cervical dyskeratosis has an increased amount of estrogens.The involvement of human papillomavirus and transferred inflammation of the uterus and appendages also provoke cervical dyskeratosis.The following reasons may make diathermocoagulation conducted or poorly adapted treatment ectopia of the cervix.
dyskeratosis cervical diagnosis .Dimensions dyskeratosis can be shaped from tiny to huge, and cover completely with the cervix and vagina.If a gynecological examination found dyskeratosis then prescribe additional tests.For example, tiny plots might find Schiller: iodine is detected by staining of the affected areas.If the lesions occupy a large area, the cytological examination carried out smear analysis.However, when dyskeratosis atypia detected by biopsy.And use a method such as scraping of the epithelium of the cervix.This method confirms the absence of pre-cancerous changes.
dyskeratosis cervical treatment .The disease is treated by means of surgical intervention.Affected areas are often cauterize the laser, but the chemical cauterization leave behind the complications.The operation was carried out on the seventh day of the menstrual cycle.Treatment of cervical dyskeratosis requires a lot of time and patience.The use of folk methods of treatment can lead to the growth of malignant cells.