Metabolic disorders



hypoproteinemia photo Hypoproteinemia - is caused by abnormally rapid or gradual decrease in the level of total protein in the composition of the plasma component of blood.For the formation of the pathological condition need only a violation nutritional intake of belkovosoderzhaschih products.In this case, it is developing gipoproteinemicheskogo mild form of the syndrome.If hypoproteinemia develops as a result of failure in the body of the liver, which is the main regulator of protein metabolism in the human body there are serious organic changes that need immediate medical correction.

reasons gipoproteinemii

gipoproteinemii development is due to a sharp decrease in quantitative index of protein albumin fraction, and the level of globulins in blood plasma may be the same or even increased in some situations.There are many contributing factors, each of which can trigger the development of clinical manifestations of hypoproteinemia, however, a severe form of the disease occurs most often in co

njunction etiopathogenetic mechanisms.

most common etiologic factor provoking a breach of the human diet, in which sharply restricted or completely terminated fact intake of foods rich in protein.This form is characterized by hypoproteinemia slow sluggish flow and the elimination of its clinical manifestations is not difficult, since leveling gipoproteinemii need only correctly adjusted eating behavior of the patient.

next pathogenetic mechanism of hypoproteinemia is reinforced denaturation and removal of its decay products mainly through the organs of the urinary system.Unfortunately, this state is in most cases accompanied by a breach belkovosinteticheskoy liver function, exacerbating the patient's condition.A notable fact is that in case of violation of the liver in the form of the formation of protein fractions, the patient showed a significant decrease in laboratory parameters as albumin and globulins.Hypoproteinemia due to violation of the formation of protein and enhanced dissolution requires exclusively medical correction carried out in the hospital.

rare forms of hypoproteinemia is genetically determined, due to the presence of the child's birth defect in the form of a complete lack of protein fractions.In the development of this disease is crucial lack of activity patterns of the reticuloendothelial system, leading to disruption of the synthesis of globulin plasma cells.Congenital hypoproteinemia dangerous for the child development of severe infectious complications, since the sharp decline globulin fraction of the protein is inevitably accompanied by a decrease in the body's immune response against the infectious agent.

Isolated reduction globulin protein fractions with a relative indicator of normal albumin is a rare condition and its possible occurrence in such pathologies as an amyloidosis, traumatic shock, and nephrotic syndrome.In a situation where under any circumstances, it is impossible to determine the cause of hypoproteinemia, the conclusion set "Essential gipoproteinemichesky syndrome", which is extremely rare.

Symptoms and signs gipoproteinemii

most pathognomonic clinical criteria gipoproteniemii is edematous syndrome.Swelling in the hypoproteinemia can be both limited and diffuse, but in all situations is marked for persistent progressive edema syndrome.In situations where development gipoproteinemii as laboratory criterion edema syndrome, is caused by a decrease in albumin fraction isolated protein in a patient early growing signs of pleural and peritoneal exudate lead to persistent respiratory disorders.Exudation in the pericardial space is observed only in the case of critical gipoproteinemii and ends with death.

important diagnostic feature is typical localization hypoproteinemia edema in the projection of the distal portions of the lower limbs and less frequently the periorbital region.In a situation where hypoproteinemia due to liver and small intestine, at the forefront of clinical symptoms are the manifestations of the underlying disease.

Hypoproteinemia pregnancy

Hypoproteinemia during pregnancy is one of the laboratory and clinical criteria of late gestosis and on par with a significant increase of body weight, edema syndrome, proteinuria, persistent hypertension and increased convulsive readiness is threatening the lives and health of the pregnant womanstate.

long for gipoproteinemii accompanied by a pronounced decline in the protein in the blood plasma of less than 60 g / l, which is caused not only a violation belkovosinteticheskoy liver function, but also a decrease in colloid osmotic pressure of plasma type of blood component.The result of the above changes is the increased permeability of the vascular endothelium and the yield of the protein into the extracellular space.There is a clear correlation between the severity of symptoms of preeclampsia and decreased protein levels in the blood of pregnant women.

Critical hypoproteinemia provokes the development of severe complications in the form of severe thrombocytopenia and fetal malnutrition.As a result of severe kidney disease dramatically increases the risk of critical states, threatening the life of the pregnant woman and the fetus.In this regard, the emergence of a pregnant even initial signs gipoproteinemii needs immediate correction.

Treatment gipoproteinemii

Alimentary gipoproteinemii type is the most favorable in relation to the prognosis for the patient's recovery, as the treatment measures during this state are limited to the correction of eating behavior of the patient.Heavy variants of hypoproteinemia in urgent need of medical correction in the hospital.

only effective method of eliminating gipoproteinemii is prescribing, the group of anabolic steroids, the effect of which leads to increased production of a protein (intramuscular Retabolil 5 mg 1 every three weeks).To improve the effectiveness of anabolic steroid therapy should be given to complement the appointment of vitamin-drug complex action.

When showing signs of exudative pleurisy or ascites as a symptomatic treatment is applied paracentesis and thoracentesis.

Hypoproteinemia - a doctor will help ?If you have or suspect a development gipoproteinemii should immediately consult a doctor such as a hematologist, a nephrologist and Transfusiology.

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