August
12
19:53
Rheumatology

Scleroderma: symptoms, treatment

Scleroderma - is one of the most dangerous systemic diseases of connective tissue, which is based on a violation of the microcirculation in the vessels, the deposition of collagen in the skin, and later in the internal organs on the background of immune disorders.Women suffer from this disease is 5-7 times more often than men, the average age of debut scleroderma - 30-60 years.

Content

  • 1 etiology and pathogenesis of scleroderma
  • 2 Classification scleroderma
    • 2.1 Options current systemic scleroderma
    • 2.2 stages of the disease
  • 3 Scleroderma Symptoms
    • 3.1 vascular lesions
    • 3.2 Cutaneous
    • 3.3 defeat osteoarticular apparatus
    • 3.4 affected muscles
    • 3.5 defeat of the digestive tract
    • 3.6 Pulmonary
    • 3.7 Cardiac
    • 3.8 Renal
    • 3.9 nervous system
  • 4 diagnosis of scleroderma
  • 5 Systemic scleroderma: treatment
  • 6 forecast

Causes of Sclerodermadate unknown.Some importance scientists attach to genetic disorders of the immune system that are under the influ

ence of unfavorable external factors cause the disease.

main predisposing factors are:

Under the influence of adverse factors in the body fails - run autoimmune mechanisms that stimulate excessive production of connective tissue protein - collagen.Because connective tissue exists in the composition of the vessel walls, pathological changes are detected in them, thickening of the vascular membrane, the inclination vascular spasm, resulting in stagnation of blood vessels, improving its clotting, thrombus formation - clinically described disorders manifested so called syndrome of Raynaud.A key role in the development of the disease is an autoimmune reactions is given that determines the steady progression of the pathological process.

Depending on the extent of the pathological process are the following forms of the disease:

is worth noting that each of these forms of the disease is further characterized and certain vascular changes, detectable under capillaroscopy, as well as some features of the blood test.However, since this article is intended for a wide range of readers, we decided not to burden you much specific data.

All 3 classification criteria are important for the correct prognosis and selection of the most appropriate treatment.

The onset of the disease, patients complain of general weakness, fatigue, increase in body temperature to subfebrile digits (not more than 38 ºC), poor appetite, weight loss.As we can see, these complaints are general in nature and based on their suspected scleroderma, in most cases not possible.Some time after the appearance of the common symptoms patients notice signs of skin, joints and other organs and systems.

confirm the diagnosis of systemic sclerosis help following studies:

To improve the prognosis of the disease, it is important to diagnose it at the earliest possible stage and immediately after diagnosis to start treatment.A person suffering from this disease should be kept under medical supervision and regularly surveyed - only in this case it is possible the early detection of progression of scleroderma and timely correction therapy.

And another important point ... Scleroderma is not treated courses.To slow the progression of the disease requires constant long, and often life-long, receiving serious medications that have no less serious side effects.Only well-chosen therapy and full compliance with the recommendations of the doctor patient significantly improve the prognosis of the disease.

General advice:

Medication:

Treatment of manifestations of the internal organs:

prognosis of adverse systemic scleroderma and it depends on the disease and its clinical form.According to statistics, the five-year survival rate is about 70%.

forecast worsen:

timely appointment, correctly chosen treatment in most cases, significantly improves the prognosis of the disease and improve survival.

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