August
12
19:53
Infectious diseases

Epstein-Barr virus, symptoms

According to the study, half of pupils and 90% of the forties faced with the Epstein-Barr virus (EBV), have immunity to it and not even know it.This article will focus on those for whom familiarity with the virus did not go so smoothly.

Content

  • 1 Infectious mononucleosis
    • 1.1 Chronic EBV infection
  • 2 How dangerous the virus Epstein-Barr?
    • 2.1 genital ulcers associated with EBV
    • 2.2 Hemophagocytic syndrome (X-Linked Lymphoproliferative Disease)
    • 2.3 Oncological diseases associated with EBV
    • 2.4 Autoimmune diseases
    • 2.5 Chronic Fatigue Syndrome

acute form called acute EBV infectious mononucleosis (Filatov's disease).The virus enters the human body through the nasopharynx.Most often through the mouth - no wonder infectious mononucleosis was a beautiful name "kissing disease."The virus replicates in cells of the lymphoid tissues (in particular, B lymphocytes).

week after infection develops clinical picture resembling acute respiratory infections:

patients were in bed

for about a week, this time a lot of drinking, gargling and take antipyretics.No specific treatment of mononucleosis, the effectiveness of existing antiviral drugs is not proven, and antibiotics are only needed in case of joining a bacterial or fungal infection.

fever usually disappears in a week, the lymph nodes are reduced in a month, and changes in the blood and can be stored for six months.After suffering

mononucleosis in the body for a lifetime stored specific antibodies - immunoglobulin G (IgG-EBVCA, IgG-EBNA-1) that provide immunity to the virus.

If the immune response is not efficient enough, can develop a chronic viral infection of the Epstein-Barr: erased, active, generalized or atypical.

In chronic infection can be detected as the virus itself in saliva by PCR and antibodies to nuclear antigens (EBNA-IgG-1), which are formed only after 3-4 months after infection.However, the diagnosis is not enough, because the same pattern can be observed in quite a healthy carrier of the virus.Immunologists investigate the entire spectrum of antiviral antibodies at least twice.

increase in the number of IgG to VCA and EA suggesting relapse.

disease is a rare, more common in young women.In mucosa external genitalia appear quite deep and painful erosion.In most cases, in addition to developing ulcers and general symptoms typical for mononucleosis.Acyclovir, well-established in the treatment of herpes simplex type II, with genital ulcers associated with Epstein-Barr virus, was not very effective.Fortunately, rashes on their own are rarely recur.

Epstein-Barr virus can infect T cells.This will start the process leading to the destruction of blood cells - red blood cells, platelets, white blood cells.This means that in addition to the symptoms characteristic of mononucleosis (fever, lymphadenopathy, hepatosplenomegaly), the patient has anemia, hemorrhagic rash, impaired blood clotting.These phenomena may disappear spontaneously, but may lead to death, therefore, require active treatment.

Currently, the virus is not disputed role in the development of cancer:

impact of the virus on the immune system causes failures in identifying its own tissues, leading to the development of autoimmune diseases.EBV infection is among the etiological factors in the development of SLE, chronic glomerulonephritis, rheumatoid arthritis, autoimmune hepatitis, and Sjogren's syndrome.

Chronic fatigue syndrome is often associated with viruses of the herpes group (to which the Epstein-Barr virus).Typical symptoms of chronic EBV infection: increasing limfuzlah, especially cervical and axillary, sore throat and low-grade fever, combined with a pronounced asthenic syndrome.The patient complains of fatigue, loss of memory and intellect, inability to concentrate, headache and muscle pain, sleep disturbance.

generally accepted regimen EBV infection exists.In the arsenal of physicians at the moment there are nucleosides (Acyclovir, Ganciclovir, Famciclovir), immunoglobulins (Alfaglobin, Poligam), recombinant interferon (IFN, TSikloferon).However, to decide how to take and whether to do it at all, must be a competent person after a thorough investigation, including laboratory.

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