Amyloidosis - symptoms, treatment

amyloidosis - a disease associated with a violation of protein metabolism.In this case, mainly in the liver synthesized particular protein - amyloid.This protein is deposited in the tissues of one or more organs, causing the corresponding symptoms.

most often develop amyloidosis in rheumatoid arthritis, ankylosing spondylitis, at least - in other systemic connective tissue diseases.
Amyloidosis affects mainly the kidneys and liver, spleen, tongue and other parts of the gastrointestinal tract, joints, heart, skin and others.


  • 1 Kidney damage in amyloidosis
  • 2 Other symptoms of amyloidosis
  • 3 treatment of amyloidosis
    • 3.1 What can you do?
    • 3.2 What can a doctor do?

Kidney damage is very common to amyloidosis.

Stage renal amyloidosis:

a result of amyloid deposits in the liver occurs an increase.It manifests a constant weight, pain in the right upper quadrant.Can increase the pressure in the veins that carry blood to the liver, portal hypertension occurs.It is characteri

zed by the accumulation of fluid in the abdomen and increasing abdomen (ascites), the appearance of varicose veins on the skin of the abdomen as the head of Medusa the Gorgon, diverging from the navel in different directions.Sometimes there is a stagnation of the bile ducts within the liver, which is manifested by itching skin, yellowing of the sclera, and in severe cases - and skin.

Enlargement of the spleen often does not manifest itself, but increases the risk of rupture of the body with a slight abdominal trauma.

amyloid deposition in the language leads to its increase.Sometimes the language is not increased, but loses flexibility and highly compacted.

defeat of the esophagus, stomach, intestine, can cause bleeding from the walls of these organs, which is manifested symptoms of bleeding (pallor, cold sweats, weakness, loss of consciousness).Sometimes massive amyloid deposits cause the phenomenon of intestinal obstruction - abdominal pain, bloating, lack of chairs.
the deposition of amyloid in the gut wall violated its absorptive function.There is a malabsorption syndrome, t. E. Poor absorption.It is accompanied by persistent diarrhea, a sharp weight loss.
Amyloid may be delayed in the articular cartilage, thus there is arthritis.Affects the wrist, shoulder, knee joints, usually symmetrical.Joints become swollen, a little painful.

the deposition of amyloid in the muscles, they are sealed, increase in volume.Develops muscle weakness.It may be determined by carpal tunnel syndrome - numbness and pain in the first three fingers extending to the forearm.
Because of cyst formation in the bones of their possible fractures.
With the defeat of the respiratory system appears hoarseness, and sometimes - signs surround formation in the lungs (cough, dyspnea).
Sometimes there is heart disease.It is shown that an increase in body rhythm disorders.Gradually developing heart failure - there is shortness of breath with exertion, and then alone.Later joined by swelling.If amyloid is deposited in the walls of the coronary vessels, the attacks may appear similar to angina pectoris: a pressing, burning chest pain with exertion, and then alone.
skin lesion appears slightly form towering above the surface of plaques - plaques.They do not itch, have a waxy appearance, located mainly in the axillary, anal, groin and on the face and neck.Easy finger rubbing these plaques can cause subcutaneous hemorrhage.Sometimes there is a hemorrhagic syndrome (increased bleeding) with bleeding around the eyes ("raccoon eyes", "symptom points").
When amyloidosis affected the nervous system.There are signs of peripheral nerves.Sensitivity can be violated, there is pain in different parts of the body.If it affects the motor nerves arise movement disorders, paralysis.Characteristically the gradual spread of such violations from remote areas limbs (distal) to closer to the trunk (proximal).
involvement of the autonomic nervous system shows a tendency to a sharp drop in blood pressure when moving from a horizontal to a vertical position (orthostatic hypotension).Also, there is a movement disorder of the intestine and diarrhea.Characterized by dysfunction of the pelvic organs, including erectile dysfunction.

Main line treatment of amyloidosis - treatment of the underlying disease.When remission rheumatic disease have improved, and sometimes even reverse the development of amyloidosis.
Appointment of large doses of vitamin C, eating raw liver inefficient, though earlier these methods were applied.

Medication actually amyloidosis - a long and difficult process.
First, you need to treat the underlying condition that caused the amyloidosis.
In the treatment of various forms of amyloidosis using a combination of cytostatic, glucocorticosteroid funds, melphalan, colchicine, and others. Treatment is often the nature of the course.It can be used
therapy with autologous stem cells (undifferentiated cells of the body's own).
When renal amyloidosis used introduction of fresh frozen plasma and protein drugs to maintain the level of protein in the blood.Patients in azotemicheskoy stage renal lesion held hemodialysis.Kidney transplantation;However, with the progression of the underlying disease, and the transplanted kidney will undergo amyloidosis.
the treatment of heart failure in amyloidosis used loop diuretics (furosemide), low doses of ACE inhibitors.If you develop cardiac arrhythmias (atrioventricular block, etc.), Carried out the installation of the pacemaker.
Treatment of other symptoms of amyloidosis is sporadic, aimed at reducing their severity and improvement of health of the patient.About

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